Computational analysis of EBNA1 “druggability” suggests novel insights for Epstein-Barr virus inhibitor design
نویسندگان
چکیده
منابع مشابه
The Epstein-Barr Virus EBNA1 Protein
Epstein-Barr virus (EBV) is a widespread human herpes virus that immortalizes cells as part of its latent infection and is a causative agent in the development of several types of lymphomas and carcinomas. Replication and stable persistence of the EBV genomes in latent infection require the viral EBNA1 protein, which binds specific DNA sequences in the viral DNA. While the roles of EBNA1 were i...
متن کاملPotential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1's role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages...
متن کاملNovel simian homologues of Epstein-Barr virus.
Thirty different lymphocryptoviruses (LCV), 26 of them novel, were detected in primates by a panherpesvirus PCR assay. Nineteen LCV from chimpanzees, bonobos, gorillas, and other Old World primates were closely related to Epstein-Barr virus (EBV), the type species of the genus lymphocryptovirus. Seven LCV originating from New World primates were related to callitrichine herpesvirus 3 (CalHV-3),...
متن کاملProtein of Epstein-Barr Virus Reveal Potential Roles for EBNA1 in Metastasis
Changes in the Nasopharyngeal Carcinoma Nuclear Proteome Induced by the EBNA1 1 Protein of Epstein-Barr Virus Reveal Potential Roles for EBNA1 in Metastasis and 2 Oxidative Stress Responses 3 Jennifer Yinuo Cao, Sheila Mansouri and Lori Frappier 4 5 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada 6 7 * Corresponding author: 8 Department of Molecular Genetics, U...
متن کاملSeropidemiology of Epstein – Barr virus infection among asymptomatic
Introduction: Epstein – Barr virus (EBV) is a herpesvirus which establishes a persistent life-long infection in over 95% of adults world wide. Infection is usually asymptomatic but the virus is associated with a variety of disease, including nasopharyngeal carcinoma (NPC), Burkitt’s lymphoma (BL), Multiple sclerosis MS, EBV-associated B-cell lymphoproliferative disease (BLPD), Hodgkin and non...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Computer-Aided Molecular Design
سال: 2016
ISSN: 0920-654X,1573-4951
DOI: 10.1007/s10822-016-9899-y